experimental autoimmune encephalomyelitis (EAE)-an experimental murine (uses mice) model of MS.
Hypoglycemia-a low blood glucose level. May cause mild to severe symptoms including weakness, sweating, faintness,
nausea, headache, confusion. If leff untreated, it may lead to a loss of consciousness, convulsion or even coma.
Lipoic acid (LA)- a non-specific scavenger of ROS, also decreased the phagocytosis of myelin by macrophages. In our
results, we demonstrate for the first time that ROS appear to play a regulatory role in the phagocytosis of myelin.
phagocytosis-the engulfing and usually the destruction of particulate matter by phagocytes (a cell, such as a white
blood cell, that engulfs and consumes foreign material) that serves as an important bodily defense mechanism against
Study Phase-Most clinical trials are designated as phase I, II, or III, based on the type of questions that study is seeking
In Phase I clinical trials, researchers test a new drug or treatment in a small group of people (20-80) for the first time to
evaluate its safety, determine a safe dosage range, and identify side effects.
In Phase II clinical trials, the study drug or treatment is given to a larger group of people (100-300) to see if it is
effective and to further evaluate its safety.
In Phase III studies, the study drug or treatment is given to large groups of people (1,000-3,000) to confirm its
effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the
drug or treatment to be used safely.
These phases are defined by the Food and Drug Administration in the Code of Federal Regulations.(8)
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